Gene Smith may refer to:
Gene Smith (American football) (born 1963), former general manager for the Jacksonville Jaguars,
Gene Smith (athletic director), athletic director at Ohio State University,
Gene Smith (Negro leagues pitcher) (1917-2011), Negro league baseball player,
Gene Ward Smith (born 1947), mathematician, composer and music theorist,
E. Gene Smith (1936-2010), scholar of Tibetology,
W. Eugene Smith (1918-1978), American photojournalist
